Cutting edge research from the AAN

AAN Scientific Abstracts (click to see)

The American Academy of Neurology Annual Meeting! For fifty years, the largest international meeting of neurologists on the planet. The place to go to hobnob with colleagues, try out new toys, and hear about cutting edge research in every facet of neurology. The 2010 meeting took place in Toronto this year.

There are two ways to present research at the meeting. One, the more prestigious, is in the form of a fifteen-minute talk. Competition for this is fierce. The other is a poster. Imagine an entire room filled with dividers, each divider with a big poster on each side, every one presenting scientific data. Whoever wrote the poster is expected to “stand guard” over it, answering questions from passers-by.

A poster session is generally a win-win for everyone involved. The bar to entry is low, so it’s a chance to present preliminary analyses almost a year before they appear in journals. Frequently, smart people will say things like, “why don’t you analyze the data this way rather than that way,” and by gum, they’ll be right, and it won’t be too late to do it. For young investigators, it’s a chance to get face-time with bigwigs who walk by and ask questions; for bigwigs, it’s a chance to keep and eye on who’s clearly up-and-coming, and also get the inside scoop on scientific publications that will be shortly coming down the pike. Emergency room doctors may like surprises; neurologists on the whole do not. I much prefer poster sessions to talks myself.

So let’s see what this year’s AAN meeting had to offer for cluster headache researchers, shall we?

FIFTEEN-MINUTE TALKS

Anatomical Location of Deep Brain Stimulation Electrodes in Chronic Cluster Headache (Denys Fontaine, Michel Lanteri-Minet, Yves Lazorthes, Gilles Geraud, Nelly Fabre, Patrick Mertens, Malou Navez, Serge Blond, Christian Lucas, Francois Dubois, Lemlih Ouchchane, Jean-Jacques Lemaire)

Well, this looks promising! The short answer is–the posterior hypothalamus on the same side as cluster headache attacks, and we kind of knew that already ever since Dr. Arne May first scanned a patient having a cluster attack almost fifteen years ago, but it’s nice to have confirmation. Dr. Fontaine does suggest that in treatment failures the electrode is nevertheless in the right place, so there has to be something else going on other than surgical ineptitude.

What else?

Prevalence and Epidemiologic Profile for Adolescent Chronic Migraine (CM): Results of a U.S. National Survey of Chronic Daily Headache (Richard Lipton, Aubrey Manack, Judith Ricci, Elsbeth Chee, Catherine Turkel, Paul Winner)

Migraine and White Matter Hyperintensity Volume: The EVA MRI Cohort (Tobias Kurth, Shajahal Mohamed, Pauline Maillard, Bernard Mazoyer, Carole Dufouil, Christophe Tzourio)

Hypothalamic Volume Decrease in Hypnic Headache (Dagny Holle, Steffen Naegel, Sarah Krebs, Charly Gaul, EIke Gizewski, Zaza Katsarava, Mark Obermann)

Cortical Spreading Depression Activates Trigeminovascular Neurons in Lamina I of the Spinal Trigeminal Nucleus (XiChun Zhang, Dan Levy, Rami Burstein)

Frequent Headaches in the Preadolescent Pediatric Population—A Population-Based Study (Marco Arruda, Vincenzo Guidetti, Federica Galli, Regina Albuquerque, Marcelo Bigal)

Voxel-Wise Assessment of White and Gray Matter Damage in Patients with Migraine and Different Disease Phenotypes; A Combined TBSS and VBM Study (Martina Absinta, Maria Rocca, Bruno Colombo, Andrea Falini, Giancarlo Comi, Massimo Filippi)

Depression: A Risk Factor for Migraine Chronification: Results from the American Migraine Prevalence and Prevention (AMPP) Study (SaitAshina, Dawn Buse, Aubrey Manack, Daniel Serrano, Morris Maizels, Catherine Turkel, Pilchard Lipton)

The Plasmatic Vascular Endothelial Growth Factor Level Is Decreased in Migraine Patients (Maria Toriello, Agustin Oterino, Jesus Castillo, Ana ALonso-Arranz, Montserrat Gago, Julio Pascual)

Headache as a Risk Factor for Neurovascular Events in Pediatric Brain Tumor Patients    Sarah Kranick, Cynthia Campen, Scott Kasner, Sudha Kessler, Rebecca Ichord, Daniel Licht, Sabrina Smith, Lauren Beslow, Michael Fisher

Cross-Sectional Survey of Neurologic Dysfunction and Headaches in North American Patients with Behcet’s Disease    Ilya Kister, Maria Filopoulos, Monalyn De Los Reyes Labitigan, Sara Crystal, Matthew Robbins, Joseph Herbert, Yusuf Yazici

OnabotulinumtoxinA for Treatment of Chronic Migraine: 56-Week Analysis of the PREEMPT Chronic Migraine Subgroup with Baseline Acute Headache Medication Overuse    Stephen Silberstein, Joel Saper, Michael Stein, Ronald DeGryse, Catherine Turkel

Headaches (HA) in Children and Adolescents (C/A) with NeurofibromatosisType1(NF-I) D. Elefant, A. Rothner

Oh well, it looks as if that was it for talks on cluster headache. Now let’s turn to the posters:

POSTERS

P04.001   Reversible Hypohidrosis with Topiramate Therapy for Chronic Migraine (Shira Markowitz, Matthew Flobbins, ClairCascella, Huma Sheikh, Brian Grosberg)

P01.002   Headache and Neurological Deficits with Gerebrospinal Fluid Lymphocytosis (HaNDL): Could It Be an Autoimmune Disease? GulsenAkman-Demir, Erdem Tmun, Dilaver Kaya, Burcak  Vural, ElifUgurel, Sema Icoz, Mefkure Eraksoy, Angela Vincent, Mustafa Ertas, Murat Kiirtuncu

P04.003   Application of the Kano Methodology for Evaluating Migraine Treatment Expectations Among Neurologists in Spain. The MIGREXX Study Jorge Matias-Guiu, Gonzalo Nocea, Teresa Caloto

P01.004   High Migraine Frequency May Be Associated with Increased Interictal Platelet Activation in Episodic Migraine Jill Jesurum, CindyFuller, Sylvia Lucas, Natalia Murinova, Lisa Hales, Elisa McGee

P04.005   Response of SUNCT (Short-Lasting Unilateral Neuralgiform Headaches with Conjunctival Injection and Tearing), SUNA (Short-Lasting Unilateral Neuralgiform Headaches with Autonomic Symptoms) and Primary Stabbing Headaches to Occipital Nerve Stimulation (ONS) Juana Mann, Peter Goadsby

PM.606   Lifetime Anxiety Symptoms in Migrainous Vertigo Gulden Akdal, Birgul Bald, Aysegiil Ozer, ElifOnur

P04.007   Evaluation of Efficacy and Safety of MAP0004 in Reversing Central Sensitization and Treating Migraine in Established Allodynic Patients Stewart
Tapper, Shashidhar Kori, Scott Borland, Min Wang, Bin Hu, Stephen Silberstein

P04.008   The Timing of Gastric Stasis in an Acute Migraine and Its Impact on Treatment Shashidhar Kori, Sheena Aurora

P01.009   Occipital Neuralgia as an Isolated Symptom of Bone Metastasis Caused by Hepatocellular Carcinoma Myung-GooJi, NamHeeKim

P04.010   Posttraumatic and Postsurgical Nummular Headache Brian Grosberg, Jelena Pavlovic, Matthew Robbins, Un Napchan, Seymour Solomon, Richard Lipton

P04.011   Clinical Phenotypes and Morphological Changes of the Circle of Willis in Migraineurs Ken tkeda, Himnoto, Konosuke Iwamoto, Kiyoko Murata, Yuji Kawase, Osamu Kano, Kiyokazu Kawabe, Hiroaki Iguchi, Yasuo Iwasaki

P04.012   Syncopal Migraine: Migraine as a Cause of Syncope David Curfman, Michael Chilungu, Robert Daroff, Amer Alshekhlee, Gisela Chelimsky, Thomas Chelimsky

P04.013   Putative Clinical, Mechanical and Local Paracrine Mechanisms of Pituitary Adenoma-Attributed Headache Christoph Schankin, Markus Krumbholz, Anna Kristin Reifferscheid, Jennifer Linn, Walter Rachinger, Petra Sostak, Thomas Arzberger, Andreas Straube

P01.014   Spinal Subdural Collection in the Setting of a Spontaneous Cerebrospinal Fluid Leak I/era Fridman

P04.015   The Headache Under-Response to Treatment (HURT) Index: An Instrument Developed by the “Lifting the Burden” Campaign To Improve Management of Headache, Especially in Primary Care Dawn Buse, Timothy Steiner, Daniel Serrano, Michael Reed, Richard Lipton

P04.016   Scleral Buckle as a Unique Cause of Facial Pain Babak Movassaghi, David Watson

P04.017   Determinants of Migraine-Related Disability Richard Lipton, Andrew Blumenfeld, Jack Ishak, Sepideh Vamn, Ariane Kawata, Aubrey Manack, Dawn Buse, Peter Goadsby

P04.018   Magnetic Resonance Perfusion Imaging in Hemiplegic Migraine Sirinan Tazen, C. Haynes Fialsten, Margaret Jaynes, David Watson

P04.019   Migrainous Vertigo Presenting in the Perimenopause Jan Brandes, Susan Roberson, MarkBennett, David Haynes Behavioral Neurology: Language and Praxis

P06.246   Cutaneous Allodynia as a Prognostic Factor in the Treatment of Migraine with Botulinum Toxin Paul Mathew, FredCutrer, Ivan Garza

P06.247   Does Gender Affect Efficacy and Tolerability of SumaRT/Nap During the Early Intervention Treatment of Migraine? ShellyLener, Jill Palchinsky, Nathalie Richard, April Thompson

P06.248   Headache Prophylaxis Using Combination TherapyÑA Statistical Modeling Study Bibhutibhushan Mishra, Leah Gaedeke, Richard Amdur, Bernhard Samuel

P06.249   Experience with Botulinum Toxin Type A in the Treatment of Medically Intractable Pediatric Chronic Daily Headache Kamran Ahmed, Kimberly Oas, Kenneth Mack, Ivan Garza

P06.Z50   OnabotulinumtoxinA for Treatment of Chronic Migraine: Analysis of the 56-Week PREEMPT 1 Trial Sheena Aurora, Ninan Mathew, Stephen Forner, Dennis Riff, Xiaofang Lei, Catherine Turkel

P06.251   OnabotulinumtoxinA for Treatment of Chronic Migraine: Analysis of the 56-Week PREEMPT 2 Trial David Dodick, Marek Gawel, RetoAgosti, Tamara Ann Miller, Xiaofang Lei, Catherine Turkel

P06.25Z   Intracranial Hypotension Mimicking Focal Spinal Amyotrophy Enrico Ferrante, Dante Facchetti, InesArpino, Alberto Cittern, Roberta Stem

P06.253   OnabotulinumtoxinA for Chronic Migraine: PREEMPT Trials Establish a Safe and Effective Dose and Injection Paradigm Andrew Blumenfeld, Stephen Silberstein, David Dodick, Sheena Aurora, Catherine Turkel, William Binder

P06.254   Antialgic Effect of Low Intensity Laser in the Treatment of Cervicogenic Headaches Jose Special!, Renata Pizzo, Fabiola Dach, Rosane Lizarelli

P06.255   Acute Medication Use Patterns in Episodic Migraine: Results of the American Migraine Prevalence and Prevention Study (AMPP) Richard Lipton, Dawn Buse, Daniel Serrano, Wendy Golden, Ya-Ting Chen, Marcelo Bigat

P06.256   Spreading Depression: The Effects ofAntiepileptic Drugs Used in Migraine Prophylaxis Joan Baptista De Mows

P06.257   Is Telcagepant Effectivein Migraineurs Who Previously Used Opioids? AndrewHo, James Kost, Carl Dahlof, Stephen Silberstein, Samar Froman, Heather Leibensperger, Christopher Lines, Tony Ho

P06.258   Fungal Sinusitis: A Surgically Treatable Cause of Chronic Daily Headache Pedro Kowacs, Renato lachinski, Gustavo Nogueira, Ana Amelia Torres

P06.259   Efficacy of Enalapril in Migraine Prophylaxis: Does It Work Through Endothelial Dysfunction Recovery? Seyed Ali Sonbolestan, Kiyan Heshmat, Shaghayegh Javanmard, Muhammad Saadatnia

P06.260   Intravenous Valproate Sodium Aborts Migraine Headaches Rapidly Kadi Shahien, Abdalla Bowirrat, SaadAbu Saleh

P06.261   Acute Anti-Migraine Efficacy and Tolerability of Zeirix’”, a Novel lontophoretic Transdermal Patch of Sumatriptan Mark Pierce, Angel Angelov

P0B.262   Bilateral Masseter and Temporalis Hypertrophy: Case Report and Review of Literature Pinky Agarwal, Marilyn Bormmeo-Wesner, Alida Griffith

P06.263   Pulse IV Steroid and IV Valproate Combination Therapy for Sustained Relief of Chronic, Treatment Refractory Headaches in Patients with Psychiatric Disorders Hasan Askari, Muhammad Zaidi

P06.264   Regression of Chronic Migraine and High Frequency Episodic Migraine to Low Frequency Migraine through Surgery Deborah Reed, Bahman Guyumn P06.265   Spontaneous Retinal Venous Pulsations as a Window to CSF PressuresÑAre They Reliable? Paul McMonagle

P06.266   A Case of Multiple Cranial Neuropathies from Perineura] Spread of a Non-Melanoma Skin Cancer Ryan Walsh, David Capobianco

P06.267   Serial Polysomnography in Hypnic Headache Shows No Association with REM Sleep Mark Obermann, Dagny Holle, Thomas Wessendorf, Sebastian Zaremba, CharlyGaul, Hans-Christoph Diener, Zaza Katsarava

P06.268   Reversible Cerebral Vasoconstriction (RCVS) in Children and Adolescents (C/A): Its Role in Thunderclap Headaches Shalaka Indulkar, Catalina Cleves, S. Pinar Karakas, SumitParikh, A. David Hothner

P0S.269   Osmophobia Is Increased in Menstrually Associated Migraine Christine Matarese, F. Michael Cutrer

P06.270   Cardiac Autonomic Dysfunctions in Migraine Attack Dong-jin Shin, Sung-Hyouk Kim, Wook-Jin Chung, Seung-Won Seol

P06.271   A Tale of Two Systems: Cardiac Cephalalgia vs. Neurologic Cardiodynia PaulMathew, Christopher Boes, Ivan Garza

P06.Z72   Onset and Potential Initiating Factors in New Daily-Persistent Headache Matthew Robbins, Brian Grosberg, UriNapchan, Sara Crystal, Richard Lipton

P06.273   Relationship between Headache Frequency and Migraine-Related Disability in the International Burden of Migraine Study (IBMS) WilcoxTeresa, Andrew Blumenfeld, Sepideh Varon, Krista Payne, Aubrey Manack, Dawn Buse, Peter Goadsby, Richard Lipton

P06.Z74   The Effect of Serum Glucose Level on Cerebrovascular Reactivity to CO2 in Women with Migraine without Aura: Transcranial Doppler Study Using Breath Holding Method Jeong-Ho Park, Sun-Ah Park, Tae-Kyeong Lee, Ki-Bum Sung

P06.275   Impact of Nutritional Factors on the Prevalence of Headache or Migraine Catherine Buettner

P06.276   Rates and Predictors of Remission from Chronic Migraine (CM) to Episodic Migraine (EM); Results from the American Migraine Prevalence and Prevention (AMPP) Study Aubrey Manack, Dawn Buse, Daniel Serrano, Catherine Turkel, Richard Lipton

P06.277   Prevalence of Chronic Daily Headaches as a Function of Parental Headache StatusÑResults from the Attention Brazil Project” Marco Arruda, Vincenzo Guidetti, Federica Galli, Regina Albuquerque, Marcelo Bigal

P06.278   PTSD, Drug Abuse, and Migraine: New Findings from the National Comorbidity Survey Replication (NCS-R) B. Peterlin, Andrea Flosso, Fred Sheftell, David Libon, Jana Mossey, Kathleen Merikangas

P06.279   Cutaneous Allodynia–A Predictor of Migraine Chronification: A Longitudinal Population-Based Study Sail Ashing, Dawn Buse, Marcelo Bigal, Daniel Serrano, Michael Reed, Richard Lipton

P06.280   Results from an International Observational Study of Pregnancy Outcomes Following Exposure to Sumatriptan, Naratriptan, or the Fixed Dose Tablet Sumatriptan and Naproxen Sodium (SumaRT/Nap) Frederick Derosier, Marianne Cunnington

P06.Z81   Natural History of Post-Traumatic Headache: Prevalence, Impact, and Clinical Characteristics Sylvia Lucas, Jeanne Huffman, Sureyya Dikmen, Kathleen Bell

P06.282   An Analysis of Practice Guidelines on Headache Published by American Academy of Neurology Arun Antony, Najib Murr

P06.283   New Daily Persistent Headaches (NDPH)ÑFollow Up and Outcome in Children and Adolescents (C/A) Sahithya Wintrich, David Hothner

P06.284   Body Mass Index (BMI) and Migraine in the Korean Population Min Kyung Chu, Kyung Mi Oh, Byung-Gun Kirn, Jae-Myun Chung, Kwang Sou Lee, Richard Lipton

P06.285   Temporomandibular Disorders, Headache Status and Headache Frequency: A Population-Based Study Jose Special!, Daniela Goncalves,  Cinara Camparis, Marcelo Bigal

P06.286   Sex Hormone Receptor Gene Polymorphisms and Migraine: A Systematic Review and Meta-Analysis Markus Schuerks, Pamela Rist, Tobias Kurth

P06.287   Relationship between Migraine Status and Functional Outcome from Stroke Pamela Rist, Julie Buring, Tobias Kurth

P06.288   Acute Treatment of Migraine in Patients with Cardiovascular Disease or Risk Factors Wendy Golden, Marcelo Bigal, Junhua Yu, Henry Hu, Diana Brixner, Richard Lipton, Joanne LaFleur

P06.289   5-HTTLPR Polymorphism in the Serotonin Transporter Gene and Migraine; A Systematic Review and Meta- Analysis Markus Schuerks, Pamela Rist, Tobias Kurth

P06.290   Caffeine Intake in Adolescents Upon First Visit to Headache Specialty Center Chad Whyte, A. Rothner

P06.291   Association between Socioeconomic Status and Migraine with and without Aura Anke Winter, Julie Buring, Tobias Kurth

P06.292   Field Testing Chronic Migraine Criteria in the Population: Results of the German Headache Consortium (GHC) Study Zaza Katsarava, Aubrey Manack,  Min-Suk Yoon, Mark Obermann, Dagny  Holle, Peter Dommes, Catherine Turkel,  Richard Lipton, Hans-Christoph Diener

P06.293   Triptan Use as a Function of  Cardiovascular Risk. A Population-Based  Study Marcelo Bigal, Wendy Golden,  Dawn Buse, Ya-Ting Chen, Richard Lipton

P06.294   Prenatal Tabagism and  Alcohol Intake Are Associated with  Chronic Daily Headache at Childhood. A  Population-Based Study Marco Arruda,  Vincenzo Guidetti, Federica Gall’i, Regina Albuquerque, Marcelo Bigal

SC02.006    Functional MRI Suggests Iron Deposition in Pain Regulatory Nuclei in Episodic Migraine and Chronic Daily Headache Stewart Tepper, Kechung Liu, Stephen Jones, Micheal Phillips, Mark Stillman, Mary Horvat, Mark Lowe

IN3-2.007 HeadacheinResidents and Workers Exposed to World Trade Center (WTC) Dust, Gas, and Fumes Presenting for Medical Care    Sara Crystal, Joan Reibman, Mengling Liu, Kristen Babinski, Alexandra Milin, Katherine Henry

P05.270    Reversible Arterial Vasoconstriction in Sturge Weber Syndrome Presenting with Postcoital Headache and Transient Hemiplegia MatthewGrantz,Elaine Skalabrin, Michael Wilder, L. DeWitt, Benjamin Lewis, Jennifer Majersik, Juliann Allred, Amer Malik, Pegah Afra

P04.249    Orthostatic and Non- Orthostatic Headache in Postural Tachycardia Syndrome (POTS)    Ramesh Khurana, Lindsay Eisenberg

P03.011    Bartonella Cat Scratch Disease Presenting as Neuroretinitis and Headache without Lymphadenopathy JoannaGan,Alan Mandell, James Otis, Michael Perloff

P04.190    Headache in Multiple Sclerosis. Clinical and Therapeutical Correlations ChiaraMonaldini,Jay Guido Capone, Maria Luisa Caniatti, Ilaria Casetta, Susanna Guttmann, Enrico Granieri, Maria Rosaria Tola

P01.195    One-Year Prospective Study on Headache Occurrence in Multiple Sclerosis (MS) Patients Treated with Natalizumab    Dacia Dalla Libera, Bruno Colombo, Bucello Sebastiano, Pietro Annovazzi, De Feo Donatella, Martinelli Vittorio, Giancarlo Comi

And that’s the news from the world of headache! There is a poster on SUNCT (Short-Lasting Unilateral Neuralgiform Headaches with Conjunctival Injection and Tearing), which is a rare form of cluster headache that lasts only a couple of minutes. It is so rare, that fewer than a hundred cases have ever been reported. The incidence is estimated at one in a hundred thousand, which makes it 1/400th as common as cluster headache. But SUNCT gets a poster, and cluster headache does not.

So what exciting new cluster headache treatments will be appearing in the near future? None. What should we expect to see coming out in the world of cluster headache research over the next year? Nothing. Needless to say, I didn’t go to the AAN meeting this year, and this is why.

My question to my readers is–why aren’t you out picketing? Cluster headache is four times as common as muscular dystrophy, I kid you not. Cluster headache is as common as multiple sclerosis. Yet Jerry’s kids are out there raising $60 million a year for muscular dystrophy research. $100 million a year is poured into MS research. The comparable figure for cluster headache research is… well, close to zero.

But if you don’t care about cluster headache research, why should we?

11 Responses to “Cutting edge research from the AAN”

  1. Friedrich says:

    The European Headache Alliance [EHA] launched its Madrid Manifesto on Headache/Migraine Disorders on Monday, May 24th in the Spanish Parliament, Madrid.The Manifesto is a call to governments and health policy makers across Europe to recognise that the failure of healthcare systems to provide effective treatments to migraine sufferers is causing an unnecessary socio-economic burden.

    “Migraine needs to be put firmly on the political agenda,” says Audrey Craven, EHA President, “We would ask you to sign the manifesto below. The more signatures we receive the more powerful our lobby will be when we approach policy makers.”

    More: http://www.petitiononline.com/headache/petition.html

    If you like you can add a comment about cluster headache with your signature.

  2. Cindy Reynolds says:

    My synopsis of the reasons we aren’t “out there” picketing with one caveat: We soon will be!

    Collective voices.

    The average cluster headache sufferer isn’t correctly diagnosed in many cases for years. During these years the seeds of “why” are firmly planted (probably wedged sideways in the cerebrum causing secondary pain to our primary pain).

    Collective voices.

    We are told “no” you do not have a brain tumor after; scheduling the primary care physician’s appointment, seeing primary care physician, scheduling appointment with neurologist after waiting weeks to get a referral to neurologist, seeing neurologist, scheduling MRI, CAT scan or lumbar puncture, having said procedure weeks later AND during this period trying to manage the pain of cluster headache itself.

    Collective Voices.

    When the “no” you do not have a brain tumor is finally said, we are exhausted, our families are relieved, our bosses expect our now declared “able” bodies back to a full 40 hour work week and then the whispering begins.

    Most likely a period of 6 months has passed.

    If you’re episodic, maybe your cycle has ended. If it has, you think, hope, pray this was a one time event. You put the horror of the medical system experience, the pain of the acute, recurring nightly attacks and the whispers in the “DO NOT TOUCH” files of your memory.

    Collective Voices.

    If your chronic, the whispers are changing into impatience, outright direct accusations of making “all this up”, “just get over it, you can not be in that much pain” coupled with the fact that the pain IS so great that you have returned to the neurologist, filled your triptan, prednisone and verapamil prescriptions and living now only to take your next dose, hoping that “surely, this one, this tiny little pill, will end all this madness so I can have my life back”.

    And so you recede.

    You do not know another living soul with this condition.

    Collective Voices.

    You get fired, you get divorced, you run out of insurance and you continue to have 5-10 attacks every single night.

    You have no hope AND whats worse, you have very few (if any) symptoms (that others can see) to support that you have a neurological disorder not a headache. It’s called a “headache”…..”go lie down and get over it!”

    I didn’t have a “rally” because from the beginning I’ve been slammed. Slammed with pain. Slammed with fear (brain tumor). Slammed with more fear (it’s night time). And still more fear (should I commit suicide).

    Oh yes and now, of course, the most promising of medications that are being studied are classified as schedule 1 drugs with the DEA (whispers).

    Collective Voices are assembling. It’s only a whisper at the moment, but it’s “our” whisper. Not the whispering of others about us!!

    Cindy Reynolds
    Episodic from 1977 through 2008
    Chronic from 2008 to present

  3. Great Information, thanks for this fine Post. I will subscribe to your feed for updates. Also check this learning information: The Best Way To Learn Spanish

  4. annick vanblaere says:

    this is a letter from belgium. my husband has the neuralgy of horton (cluster headaches) as well. actually right now he’s in the middle of a new period of attacks, about every 2 or 3 hours, day and night. he’s very very tired, and afraid to go to sleep, cause every time he wakes up another attack starts. nexto this, he has a very bad stomach (surgery as a baby) and he has fybromalgy (muscle and bone pains). Sometimes I wonder how he manages to keep alive. Allthough, like this morning, he said he had enough and wants to end his life, but of course, between attacks, he will not say such a thing. He’s a trucker, and I’m scared that he is going to be so tired, that he will have an accident, which could involves innocent by standers. He cannot take any medecine because of his stomach, and on the other hand, he does not want to take medicines, because on many forums people tell it gets twice as bad, afterwards. Anyone who wants to give advice or wants to just talk about this, can mail us on 777webmaster@annickvanblaere.be
    for all of you who have this neuralgy, my heart is with you, cause I know what you are going through.

  5. Ronna Breuer says:

    Hey very nice blog!! Man .. Excellent .. Amazing .. I’ll bookmark your website and take the feeds also…I am happy to find a lot of useful information here in the post, we need work out more techniques in this regard, thanks for sharing. . . . . .

  6. I actually enjoy that guide for this issue,thanks for the tips!

  7. Wise are those who learn how the important thing doesn’t have always to be their main priority.

  8. toner says:

    toner…

    [...]Cluster Attack – Bringing Cluster Headache Researchers and Patients Together[...]…

  9. Love Hissom says:

    It’s good to see someone else who thinks like I do. With so much ignorance in the world these days it’s nice to know there’s someone out there who isn’t an idiot.

  10. Cindy Reynolds says:

    Dear Dr. Sewell,

    It’s been one year and seven months since I first read your challenge to all cluster headache patients for us to get active & advance the interest in treatments for our condition.

    I took it very seriously. Your words felt accusingly painful at first but then I realized you were right! We did need to get organized, speak, ask and convey our message to an audience who could invest in the fundamentals such as education and research.

    The Alliance for Headache Disorder Advocacy provided the vehicle for myself and many other cluster headache patients to be heard on March 27th, 2012 on Capital Hill. The event, known as, “Headache on the Hill”

    http://www.allianceforheadacheadvocacy.org/who_is.htm

    Led by Dr. Robert Shapiro, the event was a collaborative effort of 67 neurologists, migraine patients, cluster headache patients, attorneys and other professionals.

    Thanks for challenging me to get active!!!!

    To view photos follow the link below.

    Sincerely,
    Cindy Reynolds

    https://picasaweb.google.com/116224999681657343555/HeadacheOnTheHill2012?authuser=0&authkey=Gv1sRgCJ6t0M6lw9WZGw&feat=directlink

  11. asewell says:

    I’m glad to hear it! We shall see what happens.

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