Clinical Trials – How to get involved
Sumatriptan 4mg Statdose in the Acute Treatment of Cluster Headache
Phase IV, actively recruiting May 2008
Diamond Headache Clinic/GlaxoSmithKline
This study seeks to determine the safety and efficacy of the commercially available 4 mg StatDose formulation of sumatriptan as an acute treatment of cluster headache. Patients with both episodic cluster headache as well as chronic cluster headache will be studied. Patients must either not have started preventive treatment for cluster headache or be on a stable dose of preventive medication.
Fred G Freitag, DO
George Nissan, DO
Please refer to this study by its ClinicalTrials.gov identifier: NCT00399243
Prophylactic Treatment of Episodic Cluster Headache (candesartan)
Phase II, actively recruiting March 2005
Norwegian University of Science and Technology/AstraZeneca
The angiotensin II receptor blocker, candesartan, has in one study shown a clinically significant effect in migraine prophylaxis. It is well tolerated with side-effects not significantly different from placebo and with few drug interactions. We therefore wish to investigate the prophylactic effect in treatment of cluster in headache patients.
Erling A Tronvik, MD
+47 73 86 84 20
Please refer to this study by its ClinicalTrials.gov identifier: NCT00184587
Study of Hypothalamic Metabolism in Sporadic Cluster Headache Attacks
Assistance Publique Hopitaux De Marseille
Pôle de Neurosciences Cliniques CHU Timone
MARSEILLE, France, 13005
Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache. This prompted the application of hypothalamic deep brain stimulation. The aim of this data is to precise the localisation of the hypothalamic activation.
Anne DONNET, PH
Please refer to this study by its ClinicalTrials.gov identifier: NCT00458770
A Research Study to Examine Cutaneous Allodynia and Cluster Headache
Thomas Jefferson University/Valeant Pharmaceuticals North America
This is a research study examining cutaneous (q-tan-ee-us) allodynia (all-o-din-ee-uh) and cluster headaches. Cutaneous allodynia means the feeling of pain or unpleasant sensation when normally non-painful stimuli (e.g. light touch) are applied to the skin. Many studies have been performed looking at the presence of cutaneous allodynia in patients with migraine; however, few studies have examined it in cluster headache patients. There is still much to be learned about the brain and how it functions if we are to understand the underlying causes of cluster headache. It is important to explore cutaneous allodynia in cluster headache as it may help guide physicians with the care of these individuals.Sixty patients will be screened for this study, in order to enroll sixty subjects. Thomas Jefferson University is the only center enrolling patients in this research study.
Abraham A Ashkenazi, M.D.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00329836